Space exploration’s expansion is at risk from increasing cyberattacks on assets and control systems, making cybersecurity essential. Threats include satellite hacking, GPS spoofing, and ransomware, causing data corruption, operational disruptions, and economic damage. Case studies highlight significant breaches. Enhancing security through design, encryption, intrusion detection, and resilience is imperative. International collaboration and AI advancements will be crucial in adapting to evolving cyber threats and ensuring the safety and success of future space missions.